Ten years on from the initial UN HLM on NCDs, there is growing demand to evolve the NCD agenda with a two-fold intention: to accelerate action on the current “5x5” agenda where progress has been globally lacking and inadequate, whilst also exploring the opportunity for a more inclusive approach that leaves no one behind, a foundational principle of Agenda 2030. As the world aims to build back better from the COVID-19 pandemic, there is an opportunity to develop the current commitments and agenda in order recognise the many millions of people living with multiple NCDs and/or NCDs other than the major conditions, and ensure the agenda includes all ages, including people younger than 30 or older than 70 years. This Discussion Paper will act as a starting point from which the NCD Alliance will explore how to support advocacy calling for a Person-Centred, Inclusive NCD Agenda. You are invited to please share your comments and suggestions with [email protected] [2].